Oral Bacterial and Fungal Microbiome and Subsequent Risk for Pancreatic Cancer

Is the prediagnostic oral bacterial and fungal microbiome associated with the subsequent development of pancreatic cancer?In this cohort study including 122 000 individuals, 3 oral bacterial periodontal pathogens, an additional 20 bacteria, and 4 fungi were identified, which together conferred a more than 3-fold increase in the risk for pancreatic cancer.The oral fungal and bacterial microbiotas may serve as readily accessible, noninvasive biomarkers for subsequent pancreatic cancer risk to identify individuals at high risk of pancreatic cancer.

Corresponding Authors: Jiyoung Ahn, PhD (jiyoung.ahn@nyulangone.org), and Richard B. Hayes, DDS, PhD (richard.b.hayes@nyulangone.org), Department of Population Health, NYU Grossman School of Medicine, 522 First Ave, Smilow Research Building, Ste 1001C, New York, NY 10016.

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