Brain Imaging Biomarkers and Cognitive Outcomes in a Multidomain Lifestyle Intervention

How does a structured, high-intensity multidomain lifestyle intervention affect brain imaging biomarkers of Alzheimer disease (AD), cerebrovascular disease, and neurodegeneration or their associations with global cognition, and do relationships differ by specific subgroups?In this randomized clinical trial involving 983 participants, the structured (vs self-guided) multidomain intervention was not associated with simultaneous change in brain imaging biomarkers but was associated with better-than-expected cognitive outcomes in older adults with certain brain imaging characteristics that confer risk for cognitive decline, including lower hippocampal volume and greater medial temporal tau accumulation over time.A multidomain lifestyle intervention did not affect brain imaging biomarker trajectories, but certain at-risk, but non–AD-specific brain imaging characteristics predicted greater cognitive benefit from the more intensive, structured intervention compared with the self-guided intervention.

Corresponding Authors: Theresa M. Harrison, PhD (tessaharrison@berkeley.edu), and Susan M. Landau, PhD (slandau@berkeley.edu), UC Berkeley Neuroscience Department, 250A Warren Hall, Berkeley, CA 94709.

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