Research Letter

Concordance of Biological and Clinical Staging of Alzheimer Disease Pathology in Down Syndrome

JAMA Neurology 10.1001/jamaneurol.2025.5261

January 12, 2026 at 11:00 AM EST

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This cross-sectional study examines data for participants in the Alzheimer Biomarker Consortium–Down Syndrome study to gauge the concordance of clinical and biological Alzheimer disease staging.

Corresponding Author: Jason K. Russell, PhD, Alzheimer’s Therapeutic Research Institute, Keck School of Medicine, University of Southern California, 9860 Mesa Rim Rd, San Diego, CA 92121 (jasonkru@usc.edu).

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