Viewpoint

Chronic Pain Is a Brain Network Disorder

JAMA Neurology 10.1001/jamaneurol.2025.5065

December 22, 2025 at 11:00 AM EST

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This Viewpoint calls for a reconsideration of chronic pain as a symptom of nervous system dysfunction and recommends several neuromodulation therapies for refractory clinical pain.

Corresponding Author: Prasad Shirvalkar, MD, PhD, University of California, San Francisco, 1651 4th St, Box 3128, San Francisco, CA 94143 (prasad.shirvalkar@ucsf.edu).

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