Evaluation of Copathology and Clinical Trajectories in Individuals With Tau-Clinical Mismatch

Does tau-clinical mismatch identify individuals with copathology and differing clinical trajectories?In the Alzheimer’s Disease Neuroimaging Initiative and Penn Alzheimer’s Disease Research Center cohorts including a total of 878 participants, those with greater clinical impairment than expected for tau burden had evidence of significantly higher rates of copathology and faster clinical decline compared with those with the expected level of impairment for a given level of tau pathology.Results suggest that when individuals have a higher level of clinical impairment than expected for tau, they are more likely to have copathology and are likely to experience faster decline, which may impact treatment decisions and evaluation of response.

Corresponding Author: Christopher A. Brown, MD, PhD, University of Pennsylvania, 3710 Hamilton Walk, Goddard 504, Philadelphia, PA 19104 (christopher.brown@pennmedicine.upenn.edu).

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