Modulation of Treatment Effect on Disability by Disease Activity in Progressive Multiple Sclerosis

This meta-analysis of individual patient data from 6 clinical trials confirms the efficacy of existing therapies in patients with progressive multiple sclerosis showing disease activity and assesses the role of lesion reduction as a mediator of treatment effect.

Corresponding Author: Maria Pia Sormani, PhD, Department of Health Sciences (DISSAL), University of Genoa, Via Antonio Pastore 1, Genoa, 16132 Italy (mariapia.sormani@edu.unige.it).

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