Original Investigation

Family Resilience and Mental and Physical Health Sequelae of Pediatric TBI in Youths

JAMA Network Open 10.1001/jamanetworkopen.2026.9222

April 13, 2026 at 11:00 AM EDT

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Is the association between pediatric traumatic brain injury (TBI) and adverse mental and physical health outcomes modified by family resilience?In this cross-sectional study of 33 572 US children and adolescents (aged 6-17 years), those with medically diagnosed TBI had significantly increased odds of anxiety, depression, headaches, and chronic pain. Greater family resilience and child flourishing were associated with decreased odds of these outcomes, particularly depression, whereas adverse childhood experiences were associated with increased odds.In this study, family resilience was associated with decreased odds of depression among children with TBI.

Corresponding Author: Henry Xiang, MD, MPH, PhD, MBA, Center for Injury Research and Policy, Abigail Wexner Research Institute, Nationwide Children’s Hospital, 700 Children’s Drive, Columbus, OH 43205, USA (Xiang.30@osu.edu).

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