Low-Dose Aspirin for Cardiovascular Disease Primary Prevention in Patients With Giant Cell Arteritis

Is low-dose aspirin initiation in patients without cardiovascular disease at giant cell arteritis (GCA) diagnosis associated with risk of cardiovascular events?In this this cohort study including 14 528 patients, with 36% initiating low-dose aspirin at GCA diagnosis, low-dose aspirin was associated with reduced risk of major cardiovascular events, including all-cause mortality, at 1 year but with an increased risk of major hemorrhage. The association between low-dose aspirin and reduced cardiovascular risk was more pronounced in women and in patients with diabetes.These findings suggest that low-dose aspirin initiation at GCA diagnosis was associated with lower risk of cardiovascular events but with increased hemorrhagic risk.

Corresponding Author: Florence Tubach, Hôpital Pitié Salpêtrière, Département de Santé Publique, 47-83 Boulevard de l’hôpital, 75013, Paris (florence.tubach@aphp.fr).

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