Meat Consumption and Cognitive Health by Genotype

Is higher meat consumption associated with better cognitive health among individuals with genotypes ε3/ε4 and ε4/ε4, and does this association differ from that observed in other genotypes?In this cohort study among 2157 older adults without dementia, higher total meat consumption was associated with slower cognitive decline and a reduced dementia risk among older adults with ε3/ε4 and ε4/ε4 genotypes. Interactions by genotype were observed for trajectories of global cognition and episodic memory.These findings suggest that higher meat consumption than conventionally recommended may be associated with benefits in a genetically defined subgroup comprising approximately one-quarter of the global population.

Corresponding Author: Jakob Norgren, PhD, Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, NEO Blickagången 16, 7th Floor, 141 52 Huddinge, Sweden (jakob.norgren@ki.se).

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