Original Investigation

Poverty and Mortality Risk in Patients With Colorectal Cancer

JAMA Network Open 10.1001/jamanetworkopen.2026.6303

April 10, 2026 at 11:00 AM EDT

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Which risk factors mediate the association between living in persistent poverty areas and increased mortality?In this cohort study that included 5028 patients newly diagnosed with colorectal cancer in 382 urban census tracts, there was significant evidence of mediation by stage at diagnosis (33.7% mediation), not having surgery (29.3% mediation), and type of health insurance (13.8% mediation).These findings suggest that investments are needed to improve screening and subsequent follow-up and to facilitate the receipt of surgery, financial assistance, and other patient support programs, which may reduce the increased risk of mortality among patients with colorectal cancer in urban persistent poverty areas.

Corresponding Author: Mario Schootman, PhD, UAMS Institute for Community Health Innovation, University of Arkansas for Medical Sciences, 2708 S 48th St, Springdale, AR 72762 (mschootman@uams.edu).

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