Original Investigation

Umbilical Cord Blood Glucose Concentrations and Transitional Neonatal Hypoglycemia

JAMA Network Open 10.1001/jamanetworkopen.2026.6170

April 20, 2026 at 11:00 AM EDT

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Are umbilical cord blood glucose (UCBG) values and derived parameters associated with transitional neonatal hypoglycemia (TNH)?In this cohort study of 598 neonates, 31% developed hypoglycemia at 45 mg/dL or less and 4% at less than 30 mg/dL. Arterial and venous UCBG values, venous-arterial difference, and extraction rates were not associated with subsequent TNH.These findings suggest that UCBG parameters were not associated with subsequent TNH; however, this study provides a large, percentile-based UCBG dataset to guide future research and interpretation of neonatal glycemia.

Corresponding Author: Marcia Roeper, MD, Department of General Pediatrics, Neonatology and Pediatric Cardiology, University Children’s Hospital, Heinrich-Heine-University, Moorenstraße 5, 40225 Düsseldorf, Germany (marcia.roeper@med.uni-duesseldorf.de).

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