Causes of Excess Deaths in the US Compared With Other High-Income Countries
JAMA Network Open 10.1001/jamanetworkopen.2026.6147May 08, 2026 at 11:00 AM EDT
What causes of death accounted for excess deaths in the US compared with other high-income countries from 1999 to 2022?In this cross-sectional study of more than 63.5 million deaths in the US, circulatory diseases accounted for the largest number of excess US deaths, increasing after 2001 for ages 45 to 64 years and after 2009 for ages 65 years or older. Drug poisonings, alcohol, and suicide accounted for 24% of the increase in excess US deaths overall and most of the increase for ages 0 to 44 years.The findings suggest that the rise in excess mortality is due largely to increases in circulatory and metabolic diseases, drug poisonings, alcohol-related deaths, and suicide.
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