High-Flow Nasal Oxygen Therapy After Cardiac Surgery

In patients at increased risk of pulmonary complications undergoing cardiac surgery, does prophylactic high-flow nasal oxygen therapy (HFNOT) initiated at the time of extubation have important clinical benefits vs the use of standard oxygen therapy (SOT)?In this randomized clinical trial that included 1280 adults, HFNOT did not improve clinical outcomes compared with SOT.These findings do not support the routine implementation of prophylactic HFNOT for noninvasive respiratory support following cardiac surgery.

Corresponding Author: Andrew A. Klein, MBBS, Royal Papworth Hospital NHS Foundation Trust, Papworth Road, Cambridge Biomedical Campus, Cambridge CB2 0AY, United Kingdom (andrew.klein@nhs.net).

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