Original Investigation

Prolonged Dual Hypothermic Oxygenated Machine Perfusion for Daytime Liver Transplant

JAMA Network Open 10.1001/jamanetworkopen.2026.5039

April 02, 2026 at 11:00 AM EDT

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Is routine application of prolonged dual hypothermic oxygenated machine perfusion (DHOPE-PRO) associated with an increased proportion of daytime liver transplants?In this cohort study of 330 liver transplants, the percentage of daytime liver transplants increased from 53% to 89%, with graft preservation times extended up to 31 hours, after routine implementation of DHOPE-PRO.The findings suggest that use of DHOPE-PRO is associated with an increased proportion of daytime liver transplants and with improved surgical logistics.

Corresponding Author: Vincent E. de Meijer, MD, PhD, Department of Surgery, Section of Hepatobiliary Surgery and Liver Transplantation, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands, 9712 GZ Groningen (v.e.de.meijer@umcg.nl).

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