Original Investigation

Ultraprocessed Food Intake, Striatal Response to Food Cues, and Adiposity Gain in Children

JAMA Network Open 10.1001/jamanetworkopen.2026.40252

October 23, 2026 at 11:00 AM EDT

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In this cohort study of children of healthy weight, higher habitual UPF intake was associated with greater dorsal striatal responses to food cues and prospective increases in adiposity. These findings suggest that reward-related brain responses may be involved in associations between UPF consumption and adiposity gain during childhood.

Corresponding Author: Kathleen A. Page, MD, Division of Endocrinology and Diabetes, Department of Medicine, Keck School of Medicine, University of Southern California, 2250 Alcazar St, Los Angeles, CA 90089 (kpage@usc.edu).

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