Barriers and Facilitators of Platform Trials

What barriers and facilitators do teams encounter when conducting platform trials?In this survey study of 40 investigators experienced in conducting platform trials, respondents valued platform trials’ efficiency from shared infrastructure but noted greater planning time and need for expertise and training compared with traditional randomized trials. Perceived costs and resource requirements were uncertain, and regulatory and organizational processes were often incompatible with platform trials’ adaptive and open-ended designs.These findings suggest that successful integration of platform trials into clinical research requires better-adapted processes to appropriately and efficiently implement them when needed.

Corresponding Author: Matthias Briel, MD, PhD, CLEAR-Methods Center, Division of Clinical Epidemiology, Department of Clinical Research, University Hospital Basel, Totengaesslein 3, 4031 Basel, Switzerland (matthias.briel@usb.ch).

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