Significant Incidental Findings in the National Lung Screening Trial and Diagnosis of Extrapulmonary Cancer

What was the association between significant incidental findings (SIFs) detected on low-dose computed tomography screening examinations in the National Lung Screening Trial and extrapulmonary cancer diagnoses?In this cohort study of 26 445 participants, those in whom a cancer-associated SIF was detected had a higher risk of cancer diagnosis in the year following the screening examination than participants with no cancer-associated SIF.These findings suggest that certain SIFs should be evaluated as potential indicators of undiagnosed cancers.

Corresponding Author: Ilana F. Gareen, PhD, Center for Statistical Sciences, Brown University, Box G-S121-7, Providence, RI 02912 (ilana_gareen@brown.edu).

Link to the article in your story

We encourage you to link out to this article in your story using the link below. It includes an access token that will give free access to the article for your readers up to one year after publication. (The link will be live after the article publishes and embargo is lifted.)

Please see the article for additional information, including full author list, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

Need more information? Contact us.