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Genetic Ancestry and Colorectal Cancer in the All of Us Dataset

JAMA Network Open 10.1001/jamanetworkopen.2026.28789

August 12, 2026 at 11:00 AM EDT

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In this cohort study, genetic ancestry was associated with meaningful differences in CRC burden and age-specific risk. These findings suggest that a multiethnic XGBoost model may complement CRC screening as a risk-enrichment tool.

Corresponding Author: Timothy M. Pawlik, MD, PhD, MPH, MTS, MBA, Department of Surgery, The Ohio State University Wexner Medical Center and James Comprehensive Cancer Center, 395 W 12th Ave, Ste 670, Columbus, OH 43210 (tim.pawlik@osumc.edu).

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