Editor's Pick Original Investigation

Neighborhood Environmental Interventions and Opioid Overdose Rates

JAMA Network Open 10.1001/jamanetworkopen.2026.26634

July 31, 2026 at 11:00 AM EDT

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In this study of the association of neighborhood environmental interventions with opioid overdose rates, interventions analyzed in aggregate were associated with reduced fatal opioid overdoses outcomes, with no association with nonfatal outcomes. Abandoned house remediation was significantly associated with reduced fatal and nonfatal opioid overdose rates and should be considered along with other essential interventions that provide treatment and harm reduction to individuals with substance use disorder.

Corresponding Author: Eugenia C. South, MD, MS, Department of Emergency Medicine, 3400 Spruce St, Ground Ravdin, Philadelphia, PA 19104 (Eugenia.south@pennmedicine.upenn.edu).

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