Geographic and Social Equity in Population-Wide Genomic Screening

Does the integration of implementation science and informatics infrastructure support equitable access to population-wide genomic screening (PWGS) across diverse geographic and socially disadvantaged communities?In this cross-sectional study of 50 897 adults enrolled in a PWGS program in South Carolina who completed screening for hereditary breast and ovarian cancer, Lynch syndrome, and familial hypercholesterolemia, screening coverage (per 100 000 population) ranged from 700 to more than 880 across all levels of rurality and social disadvantage, respectively. Test positivity varied by rurality and social disadvantage.These findings suggest that combining implementation science with informatics infrastructure may support scalable and equitable PWGS delivery.

Corresponding Author: Kalyani Sonawane, PhD, Department of Public Health Sciences, College of Medicine, Medical University of South Carolina, 132 Cannon St, Room CS 302M, Charleston, SC 29464 (sonawane@musc.edu).

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