Letrozole and Infertility Among Males With Spermatogenic Failure

Does letrozole improve semen-based outcomes in men with spermatogenic failure?In this randomized clinical trial of 296 men with spermatogenic failure, 14.3% of participants treated with letrozole (2.5 mg daily) plus vitamins C and E achieved an upgrade in World Health Organization sperm concentration category at 3 months compared with 5.4% in those receiving vitamins C and E alone, a statistically significant difference.In this study, letrozole improved sperm concentration categories among men with spermatogenic failure, potentially enabling less invasive reproductive management.

Corresponding Author: Peng Li, MD (lipengyxy@sjtu.edu.cn), and Zheng Li, MD (lizhengboshi@sjtu.edu.cn), Department of Andrology, the Center for Men’s Health, Urologic Medical Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, No. 100 Haining Road, Hongkou District, Shanghai 200080, China.

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