Dual-Site aiTBS for Suicidal Ideation in Adolescents With Major Depressive Disorder

Is dual-site accelerated intermittent theta burst stimulation (aiTBS) targeting the left dorsolateral prefrontal cortex (DLPFC) and cerebellum more effective than single-site DLPFC stimulation in alleviating suicidal ideation among adolescents with major depressive disorder (MDD)?In this randomized clinical trial of 59 adolescents aged 12 to 18 years with MDD and suicidal ideation, dual-site aiTBS significantly reduced suicidal ideation after the 4-day treatment compared with single-site stimulation.The findings indicate that dual-site aiTBS targeting both the DLPFC and cerebellum may provide a rapid and effective treatment option for suicidal ideation in adolescents with MDD.

Corresponding Authors: Shuming Zhong, PhD (Shuming19882006@126.com), and Yanbin Jia, PhD (yanbinjia2006@163.com), Department of Psychiatry, First Affiliated Hospital of Jinan University, Guangzhou 510630, China.

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