Original Investigation

Immune-Mediated Inflammatory Diseases Following Pediatric Uveitis Diagnosis

JAMA Network Open 10.1001/jamanetworkopen.2026.13049

May 15, 2026 at 11:00 AM EDT

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What are the incidence and risk of immune-mediated inflammatory disorders (IMIDs) among pediatric patients with noninfectious uveitis without a previous history of IMIDs?In this population-based cohort study of 27 656 pediatric patients with uveitis, the cohort had a 5-year cumulative incidence of 8.5% for IMIDs and a significantly higher risk compared with that of the general population.These findings suggest that pediatric patients with uveitis should be carefully monitored for diverse IMIDs, with attention to individual patient characteristics and risk profiles.

Corresponding Author: Yong Joon Kim, MD, PhD, Department of Ophthalmology, Institute of Vision Research, Yonsei University College of Medicine, Seodaemungu Yonseiro 50, Seoul, 03722, Korea (kyjcolor@naver.com; kyjcolor@yuhs.ac).

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