Research Letter

Glucagon-Like Peptide-1 Receptor Agonist Switching and Treatment Persistence in Adults Without Diabetes

JAMA Network Open 10.1001/jamanetworkopen.2026.1272

March 10, 2026 at 11:00 AM EDT

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This cohort study evaluates glucagon-like peptide-1 (GLP-1) receptor agonist switching patterns and 12-month adherence and persistence among adults with overweight or obesity without diabetes.

Corresponding Author: Luyu Xie, PharmD, PhD, Peter O’Donnell Jr. School of Public Health, University of Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 (luyu.xie@utsouthwestern.edu).

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