Female Reproductive Cancers and the Sex Gap in Survival
JAMA Network Open 10.1001/jamanetworkopen.2026.1256March 10, 2026 at 11:00 AM EDT
What is the estimated contribution of female reproductive cancers to the differences in survival between females and males?In this cohort study of 264.4 million deaths in 20 countries between 1955 to 2020, successive cohorts of females born since the 1930s consistently experienced higher cancer mortality rates than males between ages 35 and 60 years. This female disadvantage was primarily associated with reproductive cancers, particularly breast and gynecological cancers.These findings suggest that female reproductive cancers attenuate total survival among females, including their advantage over males.
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