Risk-Stratified Transitional Care and Cardiovascular Hospitalizations by Sex

Is an acute heart failure risk algorithm and strategy for post–emergency department care and/or hospital admission similarly beneficial in females and males at reducing the composite outcome of cardiovascular hospitalization or death?In this prespecified secondary analysis of a stepped-wedge, cluster-randomized clinical trial of 5452 patients (2461 female and 2991 male), the adjusted hazard ratio for the primary outcome was 0.88 in both sexes. There was no effect modification for the trial intervention by sex.These findings suggest that the strategy of acute heart failure care may be of similar benefit in both females and males.

Corresponding Author: Douglas S. Lee, MD, PhD, Department of Medicine, ICES, University of Toronto, 2075 Bayview Ave, Rm G-106, Toronto, Ontario M4N 3M5, Canada (dlee@ices.on.ca).

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