High-Dose Vitamin D Supplementation During Pregnancy and Test-Based Cognitive Performance at Age 10 Years

Is high-dose vitamin D supplementation during pregnancy associated with improved cognition among offspring?In this post hoc analysis of a randomized clinical trial including 498 children, high-dose vitamin D supplementation was associated with better verbal and visual memory and set shift at age 10 years compared with standard-dose vitamin D, although the association with flexibility or set shift did not remain significant after false discovery rate correction.This study suggests that high-dose vitamin D supplementation during pregnancy may be associated with improved cognitive functioning at age 10 years.

Corresponding Author: Bo Chawes, MD, PhD, DMSc, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Ledreborg Alle, Gentofte, Copenhagen 2820, Denmark (chawes@copsac.com).

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