Pharmacologic Thromboprophylaxis in Medical Inpatients

What are the risks and benefits associated with in-hospital thromboprophylaxis in medical inpatients?In this systematic review and network meta-analysis of 22 randomized clinical trials, pharmacologic thromboprophylaxis was associated with relative risk reduction of symptomatic and clinically relevant venous thromboembolism. Low-molecular-weight heparin was associated with a lower risk of major bleeding.The finding that pharmacologic thromboprophylaxis reduced clinically relevant venous thromboembolism suggests that proper selection of patients is critical given the overall low absolute risk of venous thromboembolism.

Corresponding Author: Christophe Marti, Division of General Internal Medicine, University Hospitals of Geneva, 4, rue Gabrielle Perret-Gentil, CH 1211, 14 Geneva, Switzerland (christophe.marti@hug.ch).

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