Original Investigation

Medication Samples and Smoking Cessation Among Adults

JAMA Network Open 10.1001/jamanetworkopen.2026.11418

May 08, 2026 at 11:00 AM EDT

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Does provision of varenicline samples, given broadly and with minimal guidance or instruction, facilitate smoking cessation among adults who smoke?This randomized clinical trial with 651 adults who smoke found that varenicline sampling led to increases in smoking cessation relative to no medication sampling and to marginal increases in cessation relative to sampling of nicotine replacement therapies.Findings suggest that provision of a prescription cessation medication in an unguided context yields improvements in smoking cessation.

Corresponding Author: Matthew J. Carpenter, PhD, Department of Psychiatry carpente@musc.edu).

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