Appendiceal Adenocarcinoma Cytoreduction Outcomes and Perioperative Serum Tumor Marker Levels

What is the clinical utility of preoperative and postoperative serum tumor marker (TM) levels in patients with appendiceal adenocarcinoma (AA) undergoing cytoreductive surgery (CRS)?In this cohort study of 376 CRSs, TM levels were associated with tumor burden and were significantly decreased following CRS. Elevated preoperative TM levels were associated with worse disease-free survival and decreased likelihood of complete CRS, while elevated TM levels and failure to normalize TM levels following CRS were associated with worse disease-free and overall survival.The findings suggest preoperative and postoperative serum TM levels in patients with AA undergoing CRS may provide risk information and inform clinical decision-making.

Corresponding Authors: Beth A. Helmink, MD, PhD, Department of Surgical Oncology (BHelmink@mdanderson.org), and John Paul Shen, MD, Department of Gastrointestinal Medical Oncology (jshen8@mdanderson.org), The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Unit 0426, Houston, TX 77030-4009.

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