Sex-Specific Cardiometabolic Profiles and Severity of Liver Fibrosis

Are there sex-specific differences in associations between cardiometabolic risk factors and significant liver fibrosis among US adults?In this cross-sectional study of 5981 US adults from the 2017 to 2020 National Health and Nutrition Examination Survey, women had higher odds of clinically significant fibrosis in association with central adiposity, glucose intolerance, and the presence of multiple cardiometabolic risk factors compared with men.These findings suggest that women with multiple cardiometabolic risk factors may face a disproportionately higher risk of liver fibrosis, supporting the need for sex-specific screening and prevention strategies.

Corresponding Author: Jennifer L. Dodge, MPH, Division of Gastrointestinal and Liver Diseases, Department of Medicine, Keck School of Medicine, University of Southern California, Health Sciences Campus, 2250 Alcazar St, Ste 246, Los Angeles CA 90033 (jennifer.dodge@med.usc.edu).

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