Original Investigation

Learning Health Systems and Substance Use Care Cascade Achievement Among Justice-Involved Youth

JAMA Network Open 10.1001/jamanetworkopen.2025.58222

February 10, 2026 at 11:00 AM EST

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What is the effect of a learning health systems (LHS) intervention, including the youth legal system and behavioral health care, on substance use or substance use disorder (SU/D) care cascade outcomes among adolescents involved in the youth legal system?In this cluster-randomized stepped-wedge clinical trial of 5731 youths, a time-to-event analysis indicated the LHS was associated with significantly reduced time between youth arrest and SU/D risk screening. Significant interactions showed reduced times from arrest to treatment initiation and engagement for youths arrested 3.5 to 4.0 years after study start (ie, post COVID-19).These findings suggest that cross-system LHS may improve timeliness of SU/D risk screening, treatment initiation, and engagement for justice-involved youth.

Corresponding Author: Matthew C. Aalsma, PhD, Department of Pediatrics, Indiana University School of Medicine, 410 W 10th St, Indianapolis, IN 46202 (maalsma@iu.edu).

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