Original Investigation

Financial Toxicity, Hope, and Satisfaction With Life in Patients Receiving Ambulatory Cancer Care

JAMA Network Open 10.1001/jamanetworkopen.2025.57328

February 05, 2026 at 11:00 AM EST

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Is financial toxicity associated with lower life satisfaction in patients with cancer, and do psychological resources (hopefulness and social support) explain this association?In 519 patients with cancer, financial toxicity burden was associated with lower life satisfaction ( = −0.34,  < .001). This association was partially explained by lower hopefulness (−0.08 [95% CI, −0.12 to −0.03]) and less social support (−0.03 [95% CI, −0.06 to −0.01]).These results highlight the importance of hope and social support in understanding how financial strain relates to life satisfaction, providing a rationale for studying psychosocial approaches along with existing financial assistance strategies to reduce cancer-related financial toxicity.

Corresponding Author: David B. Feldman, PhD, Department of Counseling Psychology, Santa Clara University, 500 El Camino Real, Santa Clara, CA 95053 (dbfeldman@scu.edu).

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