Original Investigation

PREVENT Equation Performance in Asian and Native Hawaiian and Other Pacific Islander Groups

JAMA Network Open 10.1001/jamanetworkopen.2025.56915

February 12, 2026 at 11:00 AM EST

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How well do the PREVENT base and full equations predict 10-year risk of cardiovascular disease (CVD) in non-Hispanic Asian and Native Hawaiian and Other Pacific Islander ethnic groups?In this cohort study of 542 848 adults, the PREVENT equations demonstrated good overall discrimination and calibration for total CVD, atherosclerotic CVD, and heart failure in non-Hispanic Asian and Native Hawaiian and Other Pacific Islander groups. However, performance varied among disaggregated Asian ethnic groups.Despite overall strong performance, the observed heterogeneity within Asian and Native Hawaiian and Other Pacific Islander ethnic groups highlights the need for tailored CVD risk prediction models that account for racial and ethnic disparities.

Corresponding Author: Jaejin An, PhD, Department of Research and Evaluation, Kaiser Permanente Southern California, 100 S Los Robles, Second Floor, Pasadena, CA 91101 (jaejin.x.an@kp.org).

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