Demographic and Clinicopathologic Factors Associated With Colorectal Adenoma Recurrence

Which demographic and histopathologic factors are associated with colorectal adenoma recurrence in postpolypectomy surveillance, and how do their outcomes vary over long-term follow-up?In this cohort study of 59 667 patients (overall recurrence, 29.5%), high-grade dysplasia showed the strongest association with early recurrence, while villous histology demonstrated a late-phase (>10 years) resurgence. Sex displayed temporal heterogeneity with female patients with high-risk adenomas experiencing higher late-term (>10 years) recurrence risk than male patients.These findings suggest that both histopathologic and demographic factors show time-dependent associations with recurrence, supporting dynamic and individualized surveillance strategies.

Corresponding Authors: Xingyi Guo, PhD, Ste 330 (xingyi.guo@vumc.org), Zhijun Yin, PhD, Ste 1475 (zhijun.yin.1@vumc.org), Vanderbilt University Medical Center, 2525 West End Ave, Nashville, TN 37203.

Link to the article in your story

We encourage you to link out to this article in your story using the link below. It includes an access token that will give free access to the article for your readers up to one year after publication. (The link will be live after the article publishes and embargo is lifted.)

Please see the article for additional information, including full author list, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

Need more information? Contact us.