Original Investigation

Costs of Single Maintenance and Reliever Therapy vs Traditional Therapy for Asthma

JAMA Network Open 10.1001/jamanetworkopen.2025.56757

February 02, 2026 at 11:00 AM EST

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Does guideline-recommended single maintenance and reliever therapy (SMART) for asthma cost less than traditional therapy for US health care payers?In this economic evaluation using a decision-tree model and Monte Carlo simulation approach and including data from 11 988 participants, SMART was less costly than traditional therapy for US health care payers.The findings of this study suggest that expanding coverage of SMART could provide financial benefits to health care payers.

Corresponding Author: James G. Krings, MD, MSc, Division of Pulmonary and Critical Care Medicine, Washington University in St Louis School of Medicine, 660 S Euclid Ave, MSC 8052-43-14, St Louis, MO 63110 (kringsj@wustl.edu).

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