Original Investigation

Self-Acupressure for Fatigue in Patients Surviving Ovarian Cancer

JAMA Network Open 10.1001/jamanetworkopen.2025.56357

February 05, 2026 at 11:00 AM EST

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Does true self-acupressure, learned through a mobile app, improve cancer-related fatigue in women with ovarian cancer compared with sham self-acupressure and usual care?In this randomized clinical trial of 171 women, the proportion achieving a clinically normal fatigue level at the end of treatment was 58% for true self-acupressure, 51% for sham self-acupressure, and 18% for usual care, representing a significant difference between true or sham self-acupressure vs usual care.The findings suggest that self-acupressure, learned through a mobile app, offers a possible low-cost option for managing cancer-related fatigue in women diagnosed with ovarian cancer.

Corresponding Author: Suzanna M. Zick, ND, MPH, Department of Family Medicine and Nutritional Sciences, University of Michigan, 1018 Fuller St, Ann Arbor, MI 48105 (szick@umich.edu).

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