Peer Navigator Intervention and Opioid-Related Adverse Events for Emergency Department Patients
JAMA Network Open 10.1001/jamanetworkopen.2025.55903February 06, 2026 at 11:00 AM EST
Does a peer navigator intervention delivered to patients presenting to an emergency department (ED) after a nonfatal opioid overdose reduce subsequent opioid-related adverse events?In this randomized clinical trial of 247 patients from 4 New York City EDs, the peer intervention arm and site-directed care arm demonstrated similar numbers of opioid-related adverse events in the 12 months after baseline.These results suggest that future research should further examine impacts on other outcomes, such as mortality, and intervention modifications to enhance follow-up contacts and engagement with medications for opioid use disorder.
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