Original Investigation

Economic Evaluation of Tobacco Treatments From the Screen ASSIST Lung Cancer Screening Trial

JAMA Network Open 10.1001/jamanetworkopen.2025.55332

January 23, 2026 at 11:00 AM EST

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Of the 8 smoking cessation strategies used in the Screen ASSIST trial among patients undergoing lung cancer screening, which was most cost-effective?This economic evaluation study including 642 participants found that 8 sessions of telehealth counseling combined with 2 weeks of nicotine replacement therapy was the most cost-effective intervention, with an incremental cost per quit of $3050. Sensitivity analyses illustrate potential cost differences in alternative settings.These findings suggest that health systems can use this favorable incremental cost per quit and transparent cost estimation to promote wider implementation of the intervention.

Corresponding Author: Douglas E. Levy, PhD, Mongan Institute Health Policy Research Center, Massachusetts General Hospital, 100 Cambridge St, Ste 1600, Boston, MA 02114 (dlevy3@mgh.harvard.edu).

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