Single-Dose Liposomal Amphotericin Plus Fluconazole and Flucytosine for Cryptococcal Meningitis at a US Public Hospital

What are the outcomes of the AMBITION protocol (single-dose liposomal amphotericin with 2 weeks of fluconazole and flucytosine) compared with guideline-compliant treatment for cryptococcal meningitis (CM) among patients with HIV in high-resource settings?In this cohort study of 60 patient episodes, the AMBITION protocol had similar mortality and CM recurrence rates compared with guideline-compliant treatment, with significantly fewer adverse events and less frequent patient-directed discharges.The findings support broader adoption of the AMBITION protocol for CM in patients with HIV.

Corresponding Author: Devin Clark, MD, Division of Infectious Diseases, Los Angeles General Medical Center, 2051 Marengo St, A6E109, Los Angeles, CA 90033 (dclark2@dhs.lacounty.gov).

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