Original Investigation

Effect Modifiers of Graded Sensorimotor Retraining for Chronic Low Back Pain

JAMA Network Open 10.1001/jamanetworkopen.2025.52787

January 13, 2026 at 11:00 AM EST

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Which variables modify the effect of graded sensorimotor retraining on pain intensity and disability level at 18 weeks and 52 weeks of follow-up?In this secondary analysis of a randomized clinical trial involving 276 participants, there was limited evidence of treatment effect modification by the 8 baseline variables identified. Back perception was identified as a potential treatment effect modifier for pain intensity at the 52-week follow-up time point.These findings suggest that the benefits of graded sensorimotor retraining may be similar for all people with chronic low back pain, regardless of individual differences at baseline.

Corresponding Author: Martjie Venter, MPhysio, Neuroscience Research Australia, 139 Barker St, Randwick, 2031, Australia (m.venter@neura.edu.au).

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