Donor-Recipient Age Mismatch and Long-Term Graft Outcomes After Adolescent Liver Transplant

Among adolescent liver transplant recipients, is receiving from a donor 10 or more years older associated with worse long-term graft survival?In a nationwide case-control study of a registry cohort of 2020 adolescent recipients of liver transplants, 30% received age-mismatched grafts (donor ≥10 years older than recipient). After propensity score matching, age-mismatched transplants had inferior 10-year graft survival than when donors were less than 10 years older than recipients (62% vs 74%).These findings suggest the need for policy adjustments such as broader sharing of adolescent donor livers to improve long-term graft survival for adolescent recipients.

Corresponding Author: Kazunari Sasaki, MD, Division of Abdominal Transplantation, Department of Surgery, Stanford University Medical Center, 1000 Welch Rd, Palo Alto, CA 94304 (sasakik@stanford.edu).

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