Air Pollution and Cardiac Remodeling and Function in Patients With Breast Cancer

Is exposure to air pollutants associated with cardiac remodeling and function among women with breast cancer treated with potentially cardiotoxic therapies?In a cohort study of 580 patients with breast cancer treated with anthracyclines and/or trastuzumab, greater exposure to fine particulate matter with diameter of 2.5 µm or less and ozone was associated with worse cardiac remodeling and function and greater risk of therapy-related cardiac dysfunction. Exposure to particulate matter with diameter of 10 µm or less and nitrogen dioxide showed limited associations.This study’s comprehensive structural and functional data support the critical need for strategies to reduce fine particulate matter and ozone exposure, particularly in patients with breast cancer.

Corresponding Author: Bonnie Ky, MD, MSCE, Thalheimer Center for Cardio-Oncology, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, 3400 Civic Center Blvd, Philadelphia, PA 19104 (bonnie.ky@pennmedicine.upenn.edu).

Link to the article in your story

We encourage you to link out to this article in your story using the link below. It includes an access token that will give free access to the article for your readers up to one year after publication. (The link will be live after the article publishes and embargo is lifted.)

Please see the article for additional information, including full author list, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

Need more information? Contact us.