Original Investigation

Electronic Intervention for Patient-Managed Benzodiazepine Tapering

JAMA Network Open 10.1001/jamanetworkopen.2025.51807

January 14, 2026 at 11:00 AM EST

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Could the benefits of a patient-focused self-management intervention promoting benzodiazepine cessation be replicated in a second trial that converted it from paper and pencil to electronic format?In this randomized clinical trial of 161 primary care patients, the odds of benzodiazepine cessation at 6-month follow-up was 5.31 times higher among those who received the intervention than those not receiving the intervention, a significant difference, and the odds of at least a 25% reduction in benzodiazepine dose was 2.51 times higher in the intervention group, a nonsignificant difference.This study suggests that a freely accessible, patient-directed website tool can aid benzodiazepine cessation.

Corresponding Author: Keith Humphreys, PhD, Department of Psychiatry, Stanford University, 401 N Quarry Rd, MC: 5717, Stanford, CA 94305 (knh@stanford.edu)

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