Original Investigation

GeoSentinel Analysis of Travelers’ Diarrhea Antimicrobial Resistance Patterns

JAMA Network Open 10.1001/jamanetworkopen.2025.51089

December 22, 2025 at 11:00 AM EST

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What are the antibiotic nonsusceptibility patterns in travelers’ diarrhea at cases presenting at GeoSentinel sites?In this cross-sectional study of 859 cases, nonsusceptibility to fluoroquinolones was 75% for species, 32% for nontyphoidal species, 22% for species, and 18% for diarrheagenic species. Nonsusceptibility to macrolides was 12% for species, 16% for nontyphoidal species, and 35% for species.These findings suggest that there are wide geographic differences in antibiotic nonsusceptibility patterns in travelers’ diarrhea; antimicrobial susceptibility from culture should be obtained when possible to inform strategies for self-treatment and clinician management of travelers’ diarrhea.

Corresponding Author: Bhawana Amatya, MD, CIWEC Hospital and Travel Medicine Center, Kapurdhara Marg, Lainchaur, PO Box 12895, Kathmandu, Nepal (bhawanaz@gmail.com).

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