Five-Day Preoperative Radiation Therapy for Patients With High-Risk Soft Tissue Sarcoma

What safety and clinical outcomes are associated with a shorter 5-day preoperative radiotherapy regimen for extremity and truncal soft tissue sarcoma?In this nonrandomized phase 2 trial of 110 patients, median follow-up for the initial and expansion cohorts was 64.2 and 30.0 months, respectively. Major wound complications occurred in 33 of 110 patients (30.0%); at 2 years, 14 of 74 evaluable patients (18.9%) developed grade 2 or higher toxic effects. Two-year local control was 92.4% (95% CI, 86.3%-96.5%), and time to wound closure exceeded 6 months for 15 of 110 patients (13.6%).These findings suggest 5-day preoperative radiotherapy was associated with favorable long-term clinical outcomes, but its potential impact on time-to-wound closure should be assessed in a randomized study.

Corresponding Authors: Vishruth K. Reddy, MD, PhD, Department of Radiation Oncology, University of California, Los Angeles, 200 Medical Plaza, Ste B265, Los Angeles, CA 90095 (vishruthreddy@mednet.ucla.edu); Anusha Kalbasi, MD, Department of Radiation Oncology, Stanford Cancer Institute, Stanford University School of Medicine, 875 Blake Wilbur Dr, Stanford, CA 94305 (akalbasi@stanford.edu).

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