Incretin-Based Therapies and Post–Bariatric Surgery Alcohol Use Disorder

Is the use of incretin-based therapies (IBTs) after bariatric surgery associated with a reduced risk of alcohol use disorder (AUD) compared with non-IBT antiobesity medications?In this multi-institutional propensity-matched cohort study of nearly 8000 patients who had undergone bariatric surgery, IBT was associated with a 55% lower risk of new-onset AUD and a 41% lower risk of initiating medications for AUD, with consistent results across multiple sensitivity analyses.This study found that IBTs may be associated with neurobehavioral benefits in addition to weight loss, suggesting that they should be prioritized for patients who had undergone bariatric surgery and are at risk for AUD.

Corresponding Author: Juan Pablo Arab, MD, Division of Gastroenterology, Hepatology, and Nutrition, Department of Internal Medicine, Virginia Commonwealth University School of Medicine, 1200 E Broad St, 14th Floor, PO Box 980341, Richmond, VA 23298 (juanpablo.arab@vcuhealth.org).

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