Original Investigation

Multidisciplinary Team Support for Patients With Head and Neck Cancer Receiving Radiotherapy

JAMA Network Open 10.1001/jamanetworkopen.2025.47590

December 15, 2025 at 11:00 AM EST

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Does the Supportive Holistic Interventions by Nurses and Experts via Multidisciplinary Team (SHINE-MDT) intervention to manage nutritional and psychological symptoms reduce radiotherapy interruptions for patients with head and neck cancer compared with usual care?In this randomized clinical trial of 233 patients in China, those receiving SHINE-MDT had a significantly lower radiotherapy interruption rate (11%) than the usual care group (25%).The SHINE-MDT intervention may enhance radiotherapy delivery and patient well-being by addressing critical supportive care needs, demonstrating the value of holistic management for head and neck cancer.

Corresponding Authors: Xiaolin Hu, PhD, Department of Nursing, West China Hospital, Sichuan University/West China School of Nursing, Sichuan University, No. 17 People’s South Rd Section 3, Chengdu, Sichuan 610041, China (huxiaolin1220@126.com); Xingchen Peng, MD, Department of Biotherapy, Cancer Center, West China Hospital, Sichuan University, No. 17 People’s South Rd, Section 3, Chengdu, Sichuan 610041, China (pxx2014@163.com).

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