COVID-19 mRNA Vaccination and 4-Year All-Cause Mortality Among Adults Aged 18 to 59 Years in France

Are COVID-19 mRNA vaccines associated with the long-term risk of all-cause mortality?In this cohort study including 22.7 million vaccinated individuals and 5.9 million unvaccinated individuals, vaccinated individuals had a 74% lower risk of death from severe COVID-19 and no increased risk of all-cause mortality over a median follow-up of 45 months.These national-level results found no increased risk of 4-year all-cause mortality in individuals aged 18 to 59 years vaccinated against COVID-19, further supporting the safety of the mRNA vaccines that are being widely used worldwide.

Corresponding Author: Mahmoud Zureik, PhD, MD, EPI-PHARE, 143/147 Boulevard Anatole France, 93285 Saint-Denis Cedex, France (mahmoud.zureik@ansm.sante.fr).

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