Telemedicine Preexposure Prophylaxis Prescribing From a Large Online US Company

What are the provision characteristics and magnitude of preexposure prophylaxis care provided via telemedicine (telePrEP) in the US?This cohort study included 162 422 unique individuals who received telePrEP prescriptions from an online company from 2018 through 2025, most of whom had not previously used PrEP. TelePrEP as a proportion of total national PrEP use increased from 2% in 2020 to 19% in 2024.These findings suggest that telePrEP has become a critical part of the HIV prevention infrastructure in the US, highlighting the importance of regulations supporting its provision.

Corresponding Author: Aaron J. Siegler, PhD, Department of Epidemiology, Rollins School of Public Health, Emory University, 1518 Clifton Rd, Atlanta, GA 30322 (asiegle@emory.edu).

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